Abstract: MON 098

Use of Letrozole in a Patient with Peripheral Precocious Puberty

Presenter: Ghufran S. Babar


Abstract


Ghufran S. Babar, MD Msc, Associate Professor of Endocrinology, Children's Mercy Hospital and Clinics.3101 Broadway Blvd, Kansas City, MO 64111

Background: Precocious puberty in girls is generally defined as appearance of secondary sexual characteristics before eight years of age. Autonomous ovarian cysts represent 5% of cases and can cause peripheral precocious puberty.

view more

Ghufran S. Babar, MD Msc, Associate Professor of Endocrinology, Children's Mercy Hospital and Clinics.3101 Broadway Blvd, Kansas City, MO 64111

Background: Precocious puberty in girls is generally defined as appearance of secondary sexual characteristics before eight years of age. Autonomous ovarian cysts represent 5% of cases and can cause peripheral precocious puberty.

Case: A 6 years and 2/10 months old Caucasian girl who presented with recent onset of breast development. There was no report of pubic hair development or onset of menstrual bleeding. She has history of ADHD, no family history of precocious puberty. Physical exam showed no dysmorphic features, Tanner 3 for breast and Tanner 1 for pubic hair. No café-au-lait spots, rest of the exam was normal. Initial work-up showed a normal Cortisol, ACTH and thyroid hormone levels, DHEA-S less than 15 (0-149), LH less than 0.1 (0.0-2.7), FSH less than 0.1 (0.55-3.7), and Estradiol 297. Pelvic ultrasound showed: The right ovary is enlarged measuring 4.9 x 3 x 3.8 cm in size and is mostly replaced by a large cystic well-circumscribed structure measuring 4.4 x 3.1 x 3.2 cm. Left ovarian size was 2.5 x 1.1 x 1 cm. Pubertal appearance of the uterus. No uterine mass. She also had negative tumor markers for ovarian cancer and a negative skeletal survey. She was started on tablet Letrozole to block the estrogen production and prevent the pubertal progresion. On follow-up visit in 3 months there was no interval progression of the precocious puberty, the pelvic ultrasound showed a spontaneous resolution of the ovarian cyst. Repeat estradiol level: < 7 pg/ml. Letrozole was stopped. Subsequent follow-up in 4 months showed a sustained non-progression of puberty, no recurrence of the ovarian cyst, repeat estradiol level: 8 pg/ml.

Conclusion: This case represents a unique case of the use of Letrozole in peripheral precocious puberty to prevent its progression while the spontaneous regression of a functioning ovarian cyst was taking place.

show less

Support our sponsors


Share this PosterTalk

About PosterTalks

PosterTalks allows meeting attendees the ability to view these presentations, download or bookmark their favorite presentations, download PDF versions of the posters, ask questions, leave comments, and share presentations with their colleagues – all from the convenience of a smart phone.

Contact Us

Have a question? Click here to contact us. Need technical support? Click here to email support.

© 2018 PosterTalks and Connect BioMed. All other content and data, including data entered into this website are copyrighted by their respective owners.