Abstract: LB MON 35

ERRLR01 Is a Prognostic Indicator of Overall Survival in Breast Cancer

Presenter: Brian D. Adams, PhD


Abstract


LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifying rearrangements. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified ERRLR as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR levels were elevated in triple-negative breast cancer (TNBC) as compared to Luminal-A, Luminal-B, and HER2 breast cancer subtypes. view more

LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifying rearrangements. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified ERRLR as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR levels were elevated in triple-negative breast cancer (TNBC) as compared to Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR levels were also inversely correlated with breast cancer survival across all breast cancer patients, and upon stratification, OS in ERα- tumors correlated with negative survival outcomes, while in ERα+ tumors, ERRLR correlated with positive outcomes. This suggests ERRRL is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR correlated with distinct pathways including ­­­epithelial development and differentiation. These data suggest ERRLR could be an oncogene in TNBC, and could be a biomarker in breast cancer patients. Overall, in this study we provide strong evidence that ERRLR is prognostic in breast, that OS is dependent upon ER status, and the ERRLR is regulation by ERα signaling, and ERα-related proteins in breast cancer. Overall, the continued efforts to understand this epigenetic regulation mediated by lncRNAs in the context of cancer development will aide in the generation of more effective therapeutic strategies to treat the disease.

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