Abstract: P-662

EFFECT OF LOCAL ENDOMETRIAL INJURY IN PROLIFERATITVE PHASE IS THE SAME AS LUTEAL PHASE IN UNSELECTED INFERTILE WOMEN UNDERGOING IN VITRO FERTILIZATION.

Presenter: Ying Liu


Abstract


OBJECTIVE: To explore whether endometrial injury in proliferation phase preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) increase the clinical outcomes in unselected subfertile woman compared with injury in luteal phase.
DESIGN: This is prospective study. Patients underwent endometrial injury in proliferation phase or luteal phase preceding cycle before IVF treatment. Clinical outcomes including implantation, pregnancy, and live birth rates were analyzed. view more

OBJECTIVE: To explore whether endometrial injury in proliferation phase preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) increase the clinical outcomes in unselected subfertile woman compared with injury in luteal phase.
DESIGN: This is prospective study. Patients underwent endometrial injury in proliferation phase or luteal phase preceding cycle before IVF treatment. Clinical outcomes including implantation, pregnancy, and live birth rates were analyzed.
MATERIALS AND METHODS: A group of 142 patients, who were good responders to hormonal stimulation, were selected for this study. The inclusion criteria include: (a) infertile women indicated for IVF treatment and (b) a normal uterine cavity demonstrated by saline infusion sonogram. The exclusion criteria include: (i) endometrium with polyp or fibroid; (ii) hydrosalpinx. Recruited participants were randomized into four groups: injury group (group A: injury endometrium in proliferation phase, n=38; group B: injury endometrium in luteal phase, n=32), and non-injury group as control (group C: non-injury in proliferation phase, n=36; group D: non-injury in luteal phase, n=36). Baseline characteristics including the age, body mass index, duration, type and causes of subfertility, and Clinical outcomes including implantation, pregnancy, and live birth rates were analyzed. The SPSS statistical software (version 22.0) was used for data analysis. Quantitative data were presented as mean and SD (mean ± SD). Associations between: implantation, clinical pregnancy, live birth rates were tested by X2test. All statistical tests and the value were two-sided, and the limit of statistical significance was P<0.05.
RESULTS: 1. There were no significant differences in the baseline characteristics and cycle characteristics among the four groups, such as the dose and duration of hormonal stimulation, peak estradiol, the number of oocytes retrieved, rate of fertilization, the number of good-quality of embyos transferred. 2. Base on injury and non-injury treatment, implantation and pregnancy outcomes at our primary end points are assessed. There were no significant differences in implantation, clinical pregnancy, miscarriage rate, live birth rate between injury group and non-injury group. 3. Subgroup analysis was performed by stratifying women into those undergoing injury in proliferation phase and luteal phase. Mean implantation rates were similar among the four groups. There were also no significant differences in biochemical pregnancy, clinical pregnancy, miscarriage rate, ectopic pregnancy, multiple pregnancies, live birth rate among the four groups.
CONCLUSIONS: Endometrial injury in the cycle preceding IVF of unselected subfertile women does not increase implantation, clinical pregnancy, or live birth rates compared with non-injury to the endometrium. Furthermore, endometrial injury in the proliferation phase results in the same effects on the clinical outcomes as the luteal phase.

show less

Share this PosterTalk

About PosterTalks

PosterTalks allows meeting attendees the ability to view these presentations, download or bookmark their favorite presentations, download PDF versions of the posters, ask questions, leave comments, and share presentations with their colleagues – all from the convenience of a smart phone.

Contact Us

Have a question? Click here to contact us. Need technical support? Click here to email support.

© 2017 PosterTalks and Connect BioMed. All other content and data, including data entered into this website are copyrighted by their respective owners.