Abstract


OBJECTIVE: To compare aneuploidy rates between embryos generated from fresh donor versus frozen donor oocytes.
DESIGN: According to 2015 SART data, donor cycles accounted for ~9% of total cycles reported; 5,982 fresh oocyte cycles, 3,215 frozen oocyte cycles, and 11,238 donor FETs. Although 65% of donor cycles in 2015 were fresh, the success of vitrification, convenience, and expanded selection from donor egg banks has begun to overcome the inconvenience of donor/recipient synchronization and unpredictability of fresh cycles. view more

OBJECTIVE: To compare aneuploidy rates between embryos generated from fresh donor versus frozen donor oocytes.
DESIGN: According to 2015 SART data, donor cycles accounted for ~9% of total cycles reported; 5,982 fresh oocyte cycles, 3,215 frozen oocyte cycles, and 11,238 donor FETs. Although 65% of donor cycles in 2015 were fresh, the success of vitrification, convenience, and expanded selection from donor egg banks has begun to overcome the inconvenience of donor/recipient synchronization and unpredictability of fresh cycles.
It has been shown that embryos generated from even young donor oocytes demonstrate a rate of aneuploidy (1,2), therefore donor cycles can benefit from preimplantation genetic screening (PGS), increasing the likelihood and reducing the time to a healthy ongoing pregnancy.
MATERIALS AND METHODS: Trophectoderm biopsies from fresh and frozen blastocyst-stage embryos from donor oocyte IVF cycles were analyzed using a targeted next-generation sequencing-based PGS assay for whole chromosome and segmental (>10MB) aneuploidy. Aneuploidy rates for fresh and frozen derived embryos were calculated and compared based on egg age and number of embryos tested. Statistical significance was determined by the t-test.
RESULTS: Data from 19 clinics is summarized below.

Fresh Donor Frozen Donor p-value
Number of cycles 353 87
Total embryos 2660 393
Embryos/patient (range) 1-28 1-28
Oocyte age (range) 18-42 21-39
Oocyte age(mean +/- SEM) 25.85 +/- 0.20 26.55 +/- 0.39 0.116
Aneuploidy rate (mean +/- SEM) 34.89 +/- 1.31 34.74 +/- 2.7 0.96

CONCLUSIONS: There is a growing trend in IVF for patients to plan and select frozen oocytes from an egg bank. Additionally, as the cost of PGS has become more affordable, more patients are choosing to screen their embryos. In this cohort, there was no significant difference in the mean aneuploidy rates between fresh and frozen oocyte cycles, regardless of donor egg age or number of embryos tested. Given these findings, the use of frozen donor oocytes can be encouraged as the vitrification/thawing process appears to have no detrimental effect on rate of aneuploidy. Patients can avoid the variables and inconvenience of a fresh donation. Since approximately one third of donor cycle embryos were abnormal, routine PGS on donors can be beneficial.

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