Abstract


Objective: Independent use of oocyte cryopreservation (OC) & TEBX-PGS has rapidly increased over the past decade as these technologies have become more reliable & mainstream. Together they allow women to have children when ready & limit embryo transfer (ET) to a single euploid blastocyst (BL), even at advanced ages. Our center has performed >3000 cycles of each & now uses the technologies together. Here, we assessed whether adding TEBX-PGS to OC impacted outcomes by comparing TEBX-PGS cycles in which previously cryopreserved vs. view more

Objective: Independent use of oocyte cryopreservation (OC) & TEBX-PGS has rapidly increased over the past decade as these technologies have become more reliable & mainstream. Together they allow women to have children when ready & limit embryo transfer (ET) to a single euploid blastocyst (BL), even at advanced ages. Our center has performed >3000 cycles of each & now uses the technologies together. Here, we assessed whether adding TEBX-PGS to OC impacted outcomes by comparing TEBX-PGS cycles in which previously cryopreserved vs. fresh (FR) oocytes served as the female gamete.

Design: Retrospective case-control

Materials and Methods: 116 OC (n=88 80%. In 93 (80%) OC & 1243 (86%) FR cycles, > 1 2PN-fertilized oocyte developed into a BL suitable for TEBX (p= 0.1), with a mean of 4±3/cycle for OC & 5±4/cycle for FR (p=.01). When comparing OC to FR, a similar percentage of biopsied BL tested euploid or exhibited mosaicism. Regardless of oocyte age & freezing, transfer of 1 euploid BL resulted in similar implantation & pregnancy rates with >50% of transferred BL resulting in a live-birth in all groups.

Conclusions: OC was associated with fewer BL suitable for TEBX, but not a lower proportion of cycles with at least 1 biopsiable BL. Euploidy rate per biopsied BL, and implantation & ongoing/delivered rates per transferred euploid BL, were similar whether starting with OC or FR oocytes, regardless of age at retrieval. Thus, adding TEBX to OC appears potentially beneficial in affording single-ET and thus, singleton live birth. Patients should be counseled that OC may result in a lower BL formation rate and therefore, fewer biopsiable BL for evaluation.

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